Covalent drugs block protein function by forming a specific bond between the ligand and target protein. A covalent mechanism of action can provide many pharmacological advantages over a reversible ...

Electron-pair bonding is a central chemical paradigm. Here, we show that alongside the two classical covalent and ionic bond families, there exists a class of charge-shift (CS) bonds wherein the ...

Covalent bonding close covalent bondA bond between atoms formed when atoms share electrons to achieve a full outer shell of electrons. leads to the formation of substances with different types of ...

A structure of the drug ibrutinib. The drug ibrutinib makes a covalent bond to Bruton's tyrosine kinase, an important cancer target. Credit: RCSB PDB/Yang H. Ku Enticing atoms to share their electrons ...