Covalent drugs block protein function by forming a specific bond between the ligand and target protein. A covalent mechanism of action can provide many pharmacological advantages over a reversible ...

A structure of the drug ibrutinib. The drug ibrutinib makes a covalent bond to Bruton's tyrosine kinase, an important cancer target. Credit: RCSB PDB/Yang H. Ku Enticing atoms to share their electrons ...

Silica has a giant covalent structure containing silicon atoms (grey) and oxygen atoms (red) Learn more on properties of giant covalent compounds in this podcast. Listen to the full series on BBC ...