DNA gyrase, often referred to simply as gyrase, is an enzyme that relieves strain while double-strand DNA is being unwound by helicase. It is also known as DNA topoisomerase II. This causes negative supercoiling of the DNA. Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid, novobiocin, and ciprofloxacin. It supercoils (or relaxes positive supercoils) into DNA by looping the template so as to form a crossing, then cutting one of the double helices and passing the ot
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You are walking around with enough wire to span the solar system. It sounds impossible, but the math of biology is staggering. If you took the DNA from just a single microscopic cell in your body and uncoiled it, stretching it out in a straight line, it would measure about 2 meters (6 feet) long. That is just one cell. The average adult human body contains roughly 37 trillion cells. If you linked all that DNA together end-to-end, the total length would be roughly 74 billion kilometers. To put th
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